How to retrieve the strength and direction of association of a group of genetic variants to > 700+ immunophenotypes
The very powerful ieugwasr library allows you to query tens of thousands of GWAS summary statistics in R (available in the IEU GWAS collection ) very quickly. Below I show you a nice example of the potential of this library. Suppose we want to retrieve the strength and direction of association of a group of variants to the 700+ immunophenotypes published by Orrù et al in 2020. First, we need to authenticate with ieugwasr: ieugwasr::get_access_token() Next, we need to extract the identification codes of the summary statistics of the article by Orrù et al " Complex genetic signatures in immune cells underlie autoimmunity and inform therapy ": ieugwasr::get_access_token() gwi At this point, with a few lines of code, we can retrieve the association data for a group of variants (in this case two) and save the results in a file for each variant: i The execution speed is really fast.